Enhanced monoclonal antibody production by gradual increase of osmotic pressure
β Scribed by Jianqiang Lin; Mutsumi Takagi; Yinbo Qu; Peiji Gao; Toshiomi Yoshida
- Book ID
- 110257504
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 97 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0920-9069
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π SIMILAR VOLUMES
To determine the effect of hyperosmotic stress on the monoclonal antibody (MAb) production by calciumalginate-immobilized S3H5iy2bA2 hybridoma cells, the osmolalities of medium in the M A b production stage were varied through the addition of NaCI. The specific MAb productivity (9Mab) of immobilized
## Abstract **BACKGROUND:** Many reports have suggested that mild hypothermic culture conditions improve the specific monoclonal antibody (mAb) productivity of mammalian cells. The effect of active hypothermic growth on the mAb productivity of the hybridoma C~2~E~7~ was investigated. Hybridoma grow