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Enhanced method performances for conventional and chiral CE-ESI/MS analyses in plasma

โœ Scribed by Julie Schappler; Davy Guillarme; Josiane Prat; Jean-Luc Veuthey; Serge Rudaz

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
395 KB
Volume
27
Category
Article
ISSN
0173-0835

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## Abstract Sildenafil is a selective inhibitor of phosphodiesterase type 5 enzyme. A simple and sensitive LCโ€MS assay was developed to determine the concentration of sildenafil in human plasma. Sildenafil and omeprazole (internal standard) were extracted from the plasma with diethyl ether. The ext