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A method for quantitative analysis of an anticancer drug in human plasma with CE-ESI-TOF-MS

✍ Scribed by Anisa Elhamili; Jonas Bergquist


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
305 KB
Volume
32
Category
Article
ISSN
0173-0835

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Optimizing the extraction, separation an
✍ Anisa Elhamili; JΓΆrgen Samuelsson; Jonas Bergquist; Magnus Wetterhall πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 310 KB

## Abstract In this study, the extraction and CE‐ESI‐TOF‐MS analysis of tricyclic antidepressant (TCA) drugs imipramine, desipramine, clomipramine and norclomipramine in human plasma has been optimized. The CE capillaries were modified with ω‐iodo‐alkyl ammonium salt (M7C4I coating) to reduce analy