Enhanced aggregate formation by dopamine, L-dopa, and quinone in PC12 cells
β Scribed by Nakaso, Kazuhiro; Ito, Satoru; Yoshimoto, Yuko; Imamura, Keiko; Takeshima, Takao; Nakashima, Kenji
- Book ID
- 122858148
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 67 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0168-0102
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The effects of dopamine and L-DOPA on survival were examined in differentiated PC12 cells. Addition of dopamine to the culture medium at 3-30 M prevented cell death induced by depletion of serum and nerve growth factor (NGF). At 100 M, dopamine induced cell death. The cell-protective effect of dopam
## Abstract The effects of scoparone on dopamine biosynthesis and LβDOPAβinduced cytotoxicity in PC12 cells were investigated. PC12 cells treated with scoparone at concentrations of 100β200 ΞΌM showed a 128β136% increase in dopamine levels over the course of 24 hr. Scoparone significantly increased