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L-dopa and dopamine enhance the formation of aggregates under proteasome inhibition in PC12 cells

✍ Scribed by Yuko Yoshimoto; Kazuhiro Nakaso; Kenji Nakashima

Book ID
116465282
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
566 KB
Volume
579
Category
Article
ISSN
0014-5793

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## Abstract The effects of scoparone on dopamine biosynthesis and L‐DOPA‐induced cytotoxicity in PC12 cells were investigated. PC12 cells treated with scoparone at concentrations of 100–200 ΞΌM showed a 128–136% increase in dopamine levels over the course of 24 hr. Scoparone significantly increased