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Aggravation of l-DOPA-induced neurotoxicity by tetrahydropapaveroline in PC12 cells

✍ Scribed by Jae Joon Lee; Yu Mi Kim; Shou Yu Yin; Hee Dong Park; Min Hee Kang; Jin Tae Hong; Myung Koo Lee

Book ID
113993641
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
292 KB
Volume
66
Category
Article
ISSN
0006-2952

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## Abstract The effects of scoparone on dopamine biosynthesis and L‐DOPA‐induced cytotoxicity in PC12 cells were investigated. PC12 cells treated with scoparone at concentrations of 100–200 ΞΌM showed a 128–136% increase in dopamine levels over the course of 24 hr. Scoparone significantly increased