## Abstract In recent years, research on interferon (IFN)‐induced depressive symptoms in antivirally treated patients suffering from chronic hepatitis C (CHC) has considerably intensified. Profound scientific knowledge of this complication is of great relevance with regard to adherence, compliance,
Engineering approaches for the assessment of low constraint fracture conditions: A critical review
✍ Scribed by S. Cicero; R.A. Ainsworth; F. Gutiérrez-Solana
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 582 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0013-7944
No coin nor oath required. For personal study only.
✦ Synopsis
In the last two decades, constraint has constituted one of the major issues in fracture mechanics and structural integrity research. The possibility of performing more adjusted, less conservative (but still safe) assessments requires, in many cases, the consideration of the constraint conditions at the crack tip in order to make better predictions of the load-bearing capacity or the critical crack dimensions. Several methodologies have been proposed, including those based on detailed micromechanical material models (local approaches) and those based on engineering approaches. Among the latter, two methodologies stand out: the two-parameter correction to K IC and the two-parameter CTOD constraint correction.
From a practical point of view, the so-called engineering approaches are of maximum interest. Here, an overview of these methodologies is presented, with special emphasis on the European FITNET Fitness-for-Service (FFS) procedure proposal for the assessment of loss of constraint and also on the Japanese IST methodology. The contributions, limitations, advantages and disadvantages of both approaches are also discussed, as well as the possible interactions and synergies between them. Finally, both constraint methodologies have been applied to three tests, showing the benefits obtained in each case (in terms of conservatism reductions) and how the assessments remain safe in all cases.
📜 SIMILAR VOLUMES
## Abstract Over the past few years, the “critical body residue” approach for assessing toxicity based on bioaccumulated chemicals has evolved into a more expansive consideration of tissue residues as the dose metric when defining dose–response relationships, evaluating mixtures, developing protect
At the bottom of page 3 (left side) of the Introduction, all mmol/g values should be mmol/g. The correct text is: A large number, possibly hundreds, of nonpolar organic compounds cause mortality within a very narrow range of whole-body tissue concentrations ( 2-8 mmol/g wet weight or about 50 mmol/
This paper describes the development and validation of procedures for measuring the acoustic properties of an individual component of an exhaust system on a test bed under engine acceleration representing realistic operating conditions. However, collection of such data requires reliable induct press