𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The tissue residue approach for toxicity assessment: Findings and critical reviews from a Society of Environmental Toxicology and Chemistry Pellston Workshop

✍ Scribed by James P Meador; William J Adams; Beate I Escher; Lynn S McCarty; Anne E McElroy; Keith G Sappington

Publisher
Society of Environmental Toxicology and Chemistry
Year
2010
Tongue
English
Weight
97 KB
Volume
7
Category
Article
ISSN
1551-3777

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Over the past few years, the “critical body residue” approach for assessing toxicity based on bioaccumulated chemicals has evolved into a more expansive consideration of tissue residues as the dose metric when defining dose–response relationships, evaluating mixtures, developing protective guidelines, and conducting risk assessments. Hence, scientists refer to “tissue residue approach for toxicity assessment” or “tissue residue‐effects approach” (TRA) when addressing ecotoxicology issues pertaining to tissue (or internal) concentrations. This introduction provides an overview of a SETAC Pellston Workshop held in 2007 to review the state of the science for using tissue residues as the dose metric in environmental toxicology. The key findings of the workshop are presented, along with recommendations for research to enhance understanding of toxic responses within and between species, and to advance the use of the TRA in assessment and management of chemicals in the environment. Integr Environ Assess Manag 2011;7:2–6. © 2010 SETAC

📜 SIMILAR VOLUMES

Erratum: The tissue residue approach for
Erratum: The tissue residue approach for toxicity assessment: Findings and critical reviews from a Society of Environmental Toxicology and Chemistry Pellston Workshop
✍ James P Meador; William J Adams; Beate I Escher; Lynn S McCarty; Anne E McElroy; 📂 Article 📅 2011 🏛 Society of Environmental Toxicology and Chemistry 🌐 English ⚖ 31 KB 👁 1 views

At the bottom of page 3 (left side) of the Introduction, all mmol/g values should be mmol/g. The correct text is: A large number, possibly hundreds, of nonpolar organic compounds cause mortality within a very narrow range of whole-body tissue concentrations ( 2-8 mmol/g wet weight or about 50 mmol/

Tissue residue approach for chemical mix
Tissue residue approach for chemical mixtures
✍ Scott Dyer; Michael St J Warne; Joseph S Meyer; Heather A Leslie; Beate I Escher 📂 Article 📅 2010 🏛 Society of Environmental Toxicology and Chemistry 🌐 English ⚖ 423 KB

## Abstract At the SETAC Pellston Workshop “The Tissue Residues Approach for Toxicity Assessment,” held in June 2007, we discussed mixture toxicology in terms of the tissue residue approach (TRA). This article reviews the literature related to the TRA for mixtures of chemicals and recommends a prac

A review of the tissue residue approach
A review of the tissue residue approach for organic and organometallic compounds in aquatic organisms
✍ Anne E. McElroy; Mace G. Barron; Nancy Beckvar; Susan B. Kane Driscoll; James P. 📂 Article 📅 2010 🏛 Society of Environmental Toxicology and Chemistry 🌐 English ⚖ 332 KB 👁 2 views

## Abstract This paper reviews the tissue residue approach (TRA) for toxicity assessment as it applies to organic chemicals and some organometallic compounds (Sn, Hg, and Pb) in aquatic organisms. Specific emphasis was placed on evaluating key factors that influence interpretation of critical body