Energy functions for protein design
โ Scribed by D Benjamin Gordon; Shannon A Marshall; Stephen L Mayot
- Book ID
- 114314905
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 492 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0959-440X
No coin nor oath required. For personal study only.
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## Abstract Protein design methods have been originally developed for the design of monomeric proteins. When applied to the more challenging task of proteinโprotein complex design, these methods yield suboptimal results. In particular, they often fail to recapitulate favorable hydrogen bonds and el
## Abstract Computational prediction of stabilizing mutations into monomeric proteins has become an almost ordinary task. Yet, computational stabilization of proteinโprotein complexes remains a challenge. Design of proteinโprotein interactions (PPIs) is impeded by the absence of an energy function