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Energy functions for protein design I: Efficient and accurate continuum electrostatics and solvation

✍ Scribed by Navin Pokala; Tracy M. Handel


Book ID
111752260
Publisher
Cold Spring Harbor Laboratory Press
Year
2004
Tongue
English
Weight
196 KB
Volume
13
Category
Article
ISSN
0961-8368

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## Abstract Protein design methods have been originally developed for the design of monomeric proteins. When applied to the more challenging task of protein–protein complex design, these methods yield suboptimal results. In particular, they often fail to recapitulate favorable hydrogen bonds and el