Endothelin 1 is a Growth Factor for Corneal Endothelium
✍ Scribed by Pascale Chollet; François Malecaze; Laurence Gouzi; Jean Louis Arne; Jean Plouet
- Book ID
- 115604737
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 499 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0014-4835
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Endothelin-I (ET-1) is an endothelium-derived 21 amino acid vasoconstrictor peptide possessing two intrachain disulfide bridges. Recently it has become evident that isoforms of ET (ET-l, -2, and -3) have a wide range of pharmacological effects in various tissues and act as autocrineiparacrine factor
## Abstract This study evaluated somatic and dendritic growth of neurons in the frontoparietal cortex of __Igf1__–/– brains. Pyramidal neuron density was increased by ∼25% (__P__ = .005) and soma size reduced by ∼10% (__P__ < .001). Golgi staining revealed that cortical layer II–III neurons exhibit