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Insulin-like growth factor 1 is essential for normal dendritic growth

✍ Scribed by Clara M. Cheng; Ronald F. Mervis; Shui-Lin Niu; Norman Salem Jr.; Lee A. Witters; Victor Tseng; Rickey Reinhardt; Carolyn A. Bondy

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
413 KB
Volume
73
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

This study evaluated somatic and dendritic growth of neurons in the frontoparietal cortex of Igf1–/– brains. Pyramidal neuron density was increased by ∼25% (P = .005) and soma size reduced by ∼10% (P < .001). Golgi staining revealed that cortical layer II–III neurons exhibited a significant reduction in dendritic length and complexity in Igf1 null mice. Dendritic spine density and presumably synaptic contacts were reduced by 16% (P = .002). Similar findings were obtained for cortical layer V and piriform cortex pyramids. Supporting a reduction in synapses, synaptotagmin levels were reduced by 30% (P < .02) in the Igf1 null brain. Investigation of factors critically involved in dendritic growth and synaptogenesis showed an ∼50% reduction in cortical CDC42 protein expression (P < .001) and an ∼10% reduction in brain cholesterol levels (P < .01) in Igf1 null mice. Evidence is presented that Igf1 deletion causes disruptions in lipid and microtubule metabolism, leading to impaired neuronal somatic and dendritic growth. Published 2003 Wiley‐Liss, Inc.

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