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Endoglin regulates transforming growth factor-beta signaling and chondrocyte function

✍ Scribed by Chi, Y.; Finnson, K.; Philip, A.; Letarte, M.; Kapoor, M.

Book ID
122152780
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
49 KB
Volume
22
Category
Article
ISSN
1063-4584

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## Abstract ## Background Fibroblasts isolated from strictures in Crohn's disease (CD) exhibit reduced responsiveness to stimulation with transforming growth factor (TGF) Ξ²1. TGF-Ξ²1, acting through the smad pathway, is critical to fibroblast-mediated intestinal fibrosis. The membrane glycoprotein,