Transforming growth factor-beta signaling and tumor angiogenesis
β Scribed by Pardali, Evangelia
- Book ID
- 118006285
- Publisher
- Frontiers in BioScience
- Year
- 2009
- Tongue
- English
- Weight
- 376 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1093-9946
- DOI
- 10.2741/3573
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Abbreviations: TGF- \(\beta\), Transforming Growth Factor-Beta; TGF- \(\alpha\), Transforming Growth Factor-Alpha; EGF, Epidermal Growth Factor; ECM, Extracellular Matrix; LAP, Latency Associated Protein; CAM, Chorio-Allantoic Membrane; PBN, Peripheral Blood Neutrophil; 5-FU, 5-Fluorouracil; 4-HC, 4
Hepatocellular carcinoma (HCC) results from the accumulation of deregulated tumor suppressor genes and/or oncogenes in hepatocytes. Inactivation of TP53 and inhibition of transforming growth factor-beta (TGF-b) signaling are among the most common molecular events in human liver cancers. Thus, we ass