𝔖 Bobbio Scriptorium
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Transforming growth factor-beta co-receptor endoglin suppresses breast cancer invasion and metastasis

✍ Scribed by LA Henry, DJ Johnson, S Lee, PR Quinlan, T Crook, AM Thompson…

Book ID
120699658
Publisher
BioMed Central
Year
2010
Tongue
English
Weight
390 KB
Volume
12
Category
Article
ISSN
1465-5411

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## Abstract Transforming growth factor‐β (TGF‐β) family members are polypeptides with dual tumor suppressive and oncogenic effects. They signal through serine/threonine kinase receptor complexes, which phosphorylate cytoplasmic mediators, the Smads. Upon phosphorylation, Smads translocate to the nu