Endogenous ADP-Ribosylation

✍ Scribed by Friedrich Koch-Nolte (eds.)

Publisher: Springer International Publishing
Year: 2015
Tongue: English
Leaves: 215
Series: Current Topics in Microbiology and Immunology 384
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:

· Evolution and detection of endogenous ADP-ribosylation

· ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)

· ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)

The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.

✦ Table of Contents

Front Matter....Pages i-viii
The Natural History of ADP-Ribosyltransferases and the ADP-Ribosylation System....Pages 3-32
Identification and Analysis of ADP-Ribosylated Proteins....Pages 33-50
Photorhabdus luminescens Toxins TccC3 and TccC5: Insecticidal ADP-Ribosyltransferases that Modify Threonine and Glutamine....Pages 53-67
Reaction Mechanism of Mono-ADP-Ribosyltransferase Based on Structures of the Complex of Enzyme and Substrate Protein....Pages 69-87
Regulation of Nitrogenase by Reversible Mono-ADP-Ribosylation....Pages 89-106
ADP-Ribosylation of P2X7: A Matter of Life and Death for Regulatory T Cells and Natural Killer T Cells....Pages 107-126
Pierisins and CARP-1: ADP-Ribosylation of DNA by ARTCs in Butterflies and Shellfish....Pages 127-149
Comparative Structural Analysis of the Putative Mono-ADP-Ribosyltransferases of the ARTD/PARP Family....Pages 153-166
Function and Regulation of the Mono-ADP-Ribosyltransferase ARTD10....Pages 167-188
Regulation of Nucleocytoplasmic Transport by ADP-Ribosylation: The Emerging Role of Karyopherin-β1 Mono-ADP-Ribosylation by ARTD15....Pages 189-209
Back Matter....Pages 211-213

✦ Subjects

Pharmacology/Toxicology; Medical Microbiology; Immunology

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