ADP-Ribosylation Reactions

✍ Scribed by Miguel Molinete, Valérie Schreiber, Frédéric Simonin, Gérard Gradwohl (auth.), Guy G. Poirier, Pierre Moreau (eds.)

• Publisher: Springer-Verlag New York
• Year: 1992
• Tongue: English
• Leaves: 437
• Edition: 1
• Category: Library

✦ Synopsis

This monograph is dedicated to one of the discoverers of poly(ADP­ ribose), Professor Paul Mandel, from the Centre de Neurochimie in Strasbourg. We would like to congratulate him for his distinguished contributions to the field of poly(ADP-ribosyl)ation and express our gratitude for his support in the last years and particularly for his encouragement for the organization of this meeting. Poly(ADP-ribose) was discovered more than 25 years ago. Since then, excellent progress has been made on the study of the mechanisms of poly(ADP­ ribose) reaction. The last five years have been particularly exciting since the development of various molecular biology techniques has revealed the complex nature of this multifunctional enzyme. Looking at the contributions presented at this meeting, it becomes obvious that more work at the molecular level is needed. Most likely, these experiments will shed some light on the functions of poly(ADP-ribose), but further ~iophysical studies will still be required to fully understand this complex enzymatic system.

✦ Table of Contents

Front Matter....Pages i-xxxvi
Front Matter....Pages 1-1
Structure and function of the human poly(ADP-ribose) polymerase....Pages 3-13
Cloning of Poly(ADP-ribose) Polymerase cDNA from Lower Eukaryotes....Pages 14-19
Molecular Biology of Human Nuclear NAD + : ADPRibosyl-transferase (polymerizing)....Pages 20-29
Strategies for Studying the Functions of PADPRP Genes on Human Chromosomes 1 and 13....Pages 30-37
Expression of the DNA-Binding Domain of Human Poly(ADP-Ribose) Polymerase as a Trans- Dominant Inhibitor of Poly(ADP-Ribosyl)ation in Transfected Eucaryotic Cell Lines....Pages 38-46
Directed Mutagenesis of Glutamic Acid 988 of Poly(ADP-ribose) Polymerase....Pages 47-52
Chicken poly(ADP-ribose) polymerase. Complete protein sequence deduced from cDNA,comparison with mammalian enzyme sequences....Pages 53-57
Nuclear poly(ADPR)Polymerase expression and activity in rat astrocytes culture: effects of bFGF....Pages 58-61
Molecular Cloning of the Rat Poly (ADP-Ribose) Polymerase Gene and Preliminary Characterization of its Promoter and 5’-Flanking Regions....Pages 62-68
Structure and Organization of the Mouse pADPRT Gene....Pages 69-72
Strategies for Expressing Analogs of PADPRP in Eukaryotic Cells....Pages 73-76
Expression and Characterization of PADPRP and a Novel Glucocorticoid-PADPRP “Finger Swapped” Protein from Escherichia coli ....Pages 77-80
Tumor Promoters, But Not EGF, Increase Nuclear Poly(ADP-Ribose) Polymerase Gene Expression in Rat Hepatocytes Initiated in Utero with DMN and Cultured After Birth in Low-Calcium Synthetic Medium....Pages 81-85
Expression of the gene for poly(ADP-ribose) polymerase and DNA polymerase beta in rat tissues and in proliferating cells....Pages 86-91
Expression of poly (ADP-ribose) polymerase in differentiating HL-60 cells....Pages 92-94
Front Matter....Pages 95-95
A Novel Model of Enzymatic Repair of UV-Induced DNA Damage in Human Cells....Pages 97-105
Poly(ADP—Ribose)Polymerase in Xenopus laevis....Pages 106-112
ADP-Ribosylation is Involved in the Integration of Exogenous DNA into the Mammalian Cell Genome, but is not Required for the Episomal Replication or Expression of Autonomously Replicating Plasmids....Pages 113-117
Inhibitors of Poly(ADP-Ribose) Polymerase Block the Infection of Mammalian Cells by Retroviral Vectors....Pages 118-124
Detection and Analysis of NAD Binding Proteins Including Poly(ADP-Ribose) Polymerase Immobilized on the Membrane....Pages 125-128
Front Matter....Pages 95-95
An in Vitro Replication System for Autonomously Replicating Mammalian Origin-Enriched Sequences....Pages 129-132
Variation in Poly(ADP-ribose) Polymerase Activity and 2’, 5’-Oligoadenylates Core Concentration in Estrogen-Stimulated Uterus and Liver of Immature and Adult Rats....Pages 133-136
Possible involvement of poly(ADP-ribose) polymerase in the brain function....Pages 137-140
Inhibition of interferon-γ-dependent induction of major histocompatibility complex class II antigen by expressing exogenous poly(ADP-ribose) synthetase gene.....Pages 141-144
ADP-ribose Polymers Bind Specifically and Non-covalently to Histones....Pages 145-148
Poly (3’-deoxyADP-ribosyl)ation of Proteins in Liver Chromatin Isolated from Rats Fed with Hepatocarcinogens....Pages 149-152
ADP-ribose Polymer Metabolism: Implications for Human Nutrition....Pages 153-162
Some aspects of nuclear and cytoplasmic ADP-ribosylation. Biological and pharmacological perspectives.....Pages 163-172
DNA Base Excision Repair Stimulates Poly(ADP-Ribose) Synthesis....Pages 173-177
Studies on Poly(ADP-Ribosyl)ation in DNA Amplification and Mammalian Longevity....Pages 178-184
DNA Topoisomerase I and Poly(ADP-Ribose) Polymerase in the Early Stages of Hepatocarcinogenesis....Pages 185-190
Poly(ADP-ribose) polymerase inhibitors induce murine melanoma cell differentiation by a mechanism independent of alterations in cAMP levels and protein kinase A activity....Pages 191-194
Enhancement of antimetabolite cytotoxicity by 3-aminobenzamide in Chinese hamster ovary cells is independent of poly(ADP-ribose) polymerase inhibition.....Pages 195-198
Evidence for the Participation of Poly(ADPribosyl)ation in Collagenase Gene Expression in Rabbit Synovial Fibroblasts after Treatment with Active Oxygen Released by Xanthin/Xanthinoxidase....Pages 199-202
Enhancement of Oncogene-Mediated Transformation in Cloned Rat Embryo Fibroblast (CREF) Cells by 3-Aminobenzamide....Pages 203-210
Control of Procollagen Gene Transcription and Prolyl Hydroxylase Activity by Poly(ADP-Ribose)....Pages 211-217
Poly(ADP-ribose) Synthesis in Lymphocytes of Systemic Lupus Erythematosus Patients....Pages 218-223
Possible involvement of poly(ADP-ribosyl)ation in phenobarbital promotion activity in rat hepatocarcinogenesis....Pages 224-227
1-Methylnicotinamide stimulates cell growth, causes DNA hypermethylation and inhibits induced differentiation of Friend erythroleukemia cells.....Pages 228-232
2-Aminobenzamide antagonizes DNA de-methylation which precedes induced differentiation of Friend erythroleukemia cells by N’-methylnicotinamide.....Pages 233-237
Front Matter....Pages 95-95
ADP-Ribosylation of Rubisco in Lettuce Chloroplasts.....Pages 238-241
In Vivo Evidence in Humans of an Association Between ADP-Ribosylation Levels in Mononuclear Leukocytes and Immune Function....Pages 242-246
Evaluation of the DNA damage and inhibition of DNA repair caused by the benzamide derivative Metoclopramide in human peripheral mononuclear leukocytes.....Pages 247-250
Nuclear ADP-Ribosyltransferase as Target Antigen in Chronic Graft-Versus-Host Disease....Pages 251-255
Induction of Poly ADP-Ribosylation in Human Malignant Cells....Pages 256-259
Proteolytic Cleavage of Poly(ADP-Ribose) Polymerase in Human Leukemia Cells Treated with Etoposide and other Cytotoxic Agents....Pages 260-268
ADP-Ribosylation of Topoisomerase II in Physiological Conditions....Pages 269-275
Regulation of DNA polymerase ß by poly(ADP-ribose) polymerase....Pages 276-281
Extensive Purification of Nuclear Poly(ADP-ribose) Glycohydrolase....Pages 282-285
Poly(ADP-Ribose)Polymerase and NMN Adenylyl-Transferase Interaction: Molecular and Immuno-Logical Studies....Pages 286-289
Covalent modification of poly (ADP-Ribose) polymerase by reactive benzamides.....Pages 290-296
Alterations in Repair of DNA Damage in Poly(ADP-Ribose) Polymerase Deficient Cell Lines....Pages 297-303
Front Matter....Pages 305-305
Amino Acid Specific Modification of Poly(ADP-ribose)polymerase with Monomers and Polymers of ADP-ribose....Pages 307-311
Enzymatic properties of poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase on chromatin....Pages 312-315
A New “Transition-State” Inhibitor Specific for Poly(ADP-ribose) Glycohydrolase....Pages 316-320
Histones Affect Polymer Patterns Produced by Poly(ADP-ribose)polymerase....Pages 321-324
Proteolytic Degradation of Poly(ADP-ribose)polymerase by Contaminating Proteases in Commercial Preparations of DNAse I....Pages 325-328
Inactivation of the Polymerase but not the DNA Binding Function of ADPRT by Destabilization of one of its Zn 2+ Coordination Centers by 6-Nitroso-1,2-Benzopyrone....Pages 329-333
Conversion of Poly(ADP-ribose) Polymerase Activity to NAD- Glycohydrolase During Retinoic Acid Induced Differentiation of HL60 Cells....Pages 334-337
Improved Assays of Poly(ADP-Ribose) Metabolizing Enzymes....Pages 338-342
Front Matter....Pages 305-305
Specific Inhibitors of Poly(ADP- Ribose) Synthetase....Pages 343-350
Automodification and NAD ASE Activity of Poly(ADP- Ribose) Polymerase....Pages 351-354
The Poly(ADP-ribose)-Protein Shuttle of Chromatin....Pages 355-361
Front Matter....Pages 363-363
Endogenous Mono-ADP-Ribosylation of Wild-Type and Mutant Elongation Factor 2 in Eukaryotic Cells....Pages 365-368
Heterogeneity of Adpribosylation Reaction in Sulfolobus solfataricus ....Pages 369-372
A novel C3-like ADP-ribosyltransferase produced by Clostridium limosum....Pages 373-376
The 52 kDa Adp-Ribosylated Protein in the Rat Heart Plasma Membrane: Is It G sa ?....Pages 377-380
Biochemical and Developmental Characterization of ADP-ribosylation Factors, A Family of 20 kDa Guanine Nucleotide-binding Proteins.....Pages 381-384
Nonenzymatic ADP-ribosylation of Cysteine....Pages 385-388
Molecular and Immunological Characterization of ADP-ribosylarginine Hydrolases....Pages 389-392
Characterization of the Family of Mammalian Genes Encoding ADP- ribosylation Factors....Pages 393-396
Purification and characterisation of NAD:Arginine mono ADP-Ribosyl Transferase from chicken erythrocytes; identification of some enzyme inhibitors.....Pages 397-401
Target Proteins for Arginine-Specific ADP-Ribosyltransferase in Chickens....Pages 402-405
NAD + Biosynthesis in Human Placenta: Characterization of Homogeneous NMN Adenylyltransferase....Pages 406-410

✦ Subjects

Biochemistry, general