β Scribed by Joseph Meites (auth.), H. James Armbrecht Ph.D., Rodney M. Coe Ph.D., Nirandon Wongsurawat M.D., F.A.C.P. (eds.)
No coin nor oath required. For personal study only.
One of the hallmarks of aging is the decreased capacity to adapt to changes in the environment. In a constant, controlled environment, it is often difficult to distinΒ guish the functioning of the young organism from that of the old. However, when stresses are applied-temperature stresses, dietary stresses, infection, emotional stresses-the differences are more apparent. Frequently, the response ofthe old is delayed and may never reach the same mag'nitude as the young. These responses, in most cases, are mediated by the neuroendocrine system, which communicates via hormones, neurotransmitters, and related substances. Thus, it is important to understand the age-related changes that take place in the secretion and act ion of these substances and how these changes relate to the well-being of the whole organism. Indeed, the "neuroendocrine theory of aging" proposes that almost all of the characteristics of aging can be accounted for by dysfunction of the neuroendocrine system. A book on endocrine function and aging is particularly relevant at this time. With the advent of the techniques of molecular biology, there has bee~ an exploΒ sion of knowledge concerning hormone secretion and action. Hormones, proΒ hormones, hormone receptors, and "second messenger" mediators rapidly are being cloned and sequenced. Such knowledge gives us important insights into the molecular workings of these substances as well as into the genetic hasis of endoΒ crine dysfunction. These new tools are now being applied to the problem of ageΒ related changes in endocrine function.
Front Matter....Pages i-xxi
Front Matter....Pages N2-N2
Alterations in Hypothalamic-Pituitary Function with Age....Pages 1-12
Alterations in Hormone Syntheses and Secretion with Age....Pages 13-25
Changes in Hormone Action with Age: Altered Calcium Mobilization and/or Responsiveness Impairs Signal Transduction....Pages 26-34
Front Matter....Pages N3-N3
Pathogenesis and Management of Non-Insulin-Dependent Diabetes Mellitus....Pages 35-47
Glucose Tolerance, Insulin Sensitivity, and Age....Pages 48-63
Front Matter....Pages 65-65
Diagnosis and Treatment of Osteoporosis....Pages 67-78
Changes in the Production and Action of 1,25-Dihydroxyvitamin D and Parathyroid Hormone with Age....Pages 79-87
Effect of Age on PTH-Stimulated Sodium Calcium Exchange Activity: Alteration at Cellular and Molecular Levels....Pages 88-98
Front Matter....Pages N5-N5
Testicular Function in the Aging Male....Pages 99-114
Management of Female Menopause....Pages 115-135
Psychological Aspects of Sexual Dysfunction in the Elderly....Pages 136-146
Front Matter....Pages N7-N7
Treatment of Hypertension in the Elderly....Pages 147-160
Macronutrients in the Diet: A Possible Association with Age-Related Hypertension....Pages 161-174
Front Matter....Pages N9-N9
Stress, Hypothalamic-Pituitary-Adrenal Function, and Aging: Focus on Corticotropin-Releasing Factor....Pages 175-185
Treating Stress Response in the Elderly....Pages 186-199
Cholesterol and Age-Related Changes in Adrenal Steroidogenesis....Pages 200-217
Age-Related Changes in Adrenal Catecholamine Content and Tyrosine Hydroxylase Gene Expression: Effects of Dietary Restriction....Pages 218-227
Back Matter....Pages 229-236
Endocrinology; Metabolic Diseases; Biochemistry, general
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