✦ LIBER ✦

Encephalopathy associated with human herpesvirus 6 in a liver transplant recipient

✍ Scribed by Paterson, David L. ;Singh, Nina ;Gayowski, Timothy ;Carrigan, Donald R. ;Marino, Ignazio R.

Publisher: Wiley (John Wiley & Sons)
Year: 1999
Tongue: English
Weight: 30 KB
Volume: 5
Category: Article
ISSN: 1074-3022
DOI: 10.1002/lt.500050504

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✦ Synopsis

Recent reports have documented human herpesvirus 6 (HHV-6) as a cause of high fever, bone marrow depression, and rash in liver transplant recipients in the absence of another known pathogen. We describe a 49-year-old liver transplant recipient who developed confusion, occipital headache, and involuntary movements of the limbs 3 weeks after orthotopic liver transplantation. HHV-6 was detected in the peripheral blood using a rapid culture assay. Examination of cere-brospinal fluid by polymerase chain reaction for HHV-6 was also positive. No other pathogens were identified. The patient improved after commencement of intravenous ganciclovir therapy. This case suggests HHV-6 needs to be considered in the differential diagnosis of unexplained confusion in liver transplant recipients.

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