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Case report: Human herpesvirus 7 associated fatal encephalitis in a peripheral blood stem cell transplant recipient

✍ Scribed by Dr. Paul K.S. Chan; Ki-Wai Chik; Ka-Fai To; Chi-Kong Li; Matthew M.K. Shing; King-Cheung Ng; Patrick M.P. Yuen; Augustine F. Cheng

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
103 KB
Volume
66
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Previous studies have suggested a neuroinvasive and neuropersistent potential of human herpesvirus 7 (HHV‐7). In this report, a case of fatal encephalitis is described and its association with HHV‐7 infection is discussed. An 8‐year‐old girl received a peripheral blood stem cell transplant for relapsed acute lymphoblastic leukaemia. The post‐transplant period was uneventful and a course of intrathecal chemotherapy was given on Day‐30. On Day‐41, she developed acute encephalopathy with diplopia and nystagmus. She ran a rapid downhill course and succumbed despite antiviral treatment. The only positive pathological finding was the multiple microscopic foci of haemorrhage associated with neuronal degeneration detected in the brain stem. All microbiological investigations were negative, except for the presence of HHV‐7 DNA in cerebrospinal fluid and brain stem tissue samples. J. Med. Virol. 66:493–496, 2002. © 2002 Wiley‐Liss, Inc.

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