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Enantiospecific synthesis of [1-3H]-(+)-pseudoephedrine hydrochloride

✍ Scribed by John A. Hill; Jeffrey D. Scharver

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
325 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The naturally occurring dextrorotary enantiomer (+)‐pseudoephedrine, 1, was synthesized (1) in the [^3^H]‐labelled form with specific activity 17.5 Ci/mmol suitable for development of a radioimmunoassay procedure. The chirally specific route from L‐alanine to [1‐^3^H]‐d‐pseudoephedrine hydrochloride was based on the use of α‐amino acids as chiral educts for asymmetric products as developed by Rapoport.

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