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Enantioseparation of tiropramide by HPLC

✍ Scribed by Jae Jeong Ryoo; Kyu Sung Heo; Eun-Soon Choi; Jung Hag Park; Wonjae Lee

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
310 KB
Volume
16
Category
Article
ISSN
0899-0042

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✦ Synopsis

Tiropramide is an antispasmodic drug that has a chiral center. Resolution of tiropramide enantiomers on various kinds of chiral stationary phases was performed by HPLC. A good resolution on a leucine-derived chiral stationary phase was found. An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases.

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## Abstract The direct HPLC enantiomeric separation of several ferrocenylalcohols on the commercially available Chiralcel OD and Chiralcel OJ columns has been evaluated in normal‐phase mode. Almost all the compounds were resolved on one or both chiral stationary phases (CSPs) with separation factor