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Comparative HPLC enantioseparation of ferrocenylalcohols on two cellulose-based chiral stationary phases

✍ Scribed by Angela Patti; Sonia Pedotti; Claudia Sanfilippo

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
327 KB
Volume
19
Category
Article
ISSN
0899-0042

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✦ Synopsis

Abstract

The direct HPLC enantiomeric separation of several ferrocenylalcohols on the commercially available Chiralcel OD and Chiralcel OJ columns has been evaluated in normal‐phase mode. Almost all the compounds were resolved on one or both chiral stationary phases (CSPs) with separation factor (α) ranging from 1.06 to 2.88 while the resolution (R~s~) varied from 0.63 to 12.70 In the separation of the α‐ferrocenylalcohols 1a–e and the phenyl analogues 2a–e, which were all resolved except 1c, a similar trend in the retention behavior for the two series of alcohols was evidenced and the selectivity was roughly complementary on the two investigated CSP. For three ferrocenylacohols, chosen as model compounds, the influence of the mobile phase composition and temperature on the enantioseparation were investigated and additional information on the chiral recognition mechanism were deduced from the chromatographic behavior of their acetylderivatives. Chirality, 2007. © 2007 Wiley‐Liss, Inc.

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