Method development strategies for the enantioseparation of drugs by capillary electrophoresis using cyclodextrins as chiral additives
Enantioseparation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using mixtures of anionic and uncharged β-cyclodextrins as chiral additives
✍ Scribed by Marianne Fillet; Philippe Hubert; Prof. Jacques Crommen
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 597 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0173-0835
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📜 SIMILAR VOLUMES
A capillary electrophoresis method was developed for the enantioseparation of three novel cyclooxygenase-2 (COX-2) inhibitor drugs (E-6259, E-6036 and E-6087) with anti-inflammatory and analgesic activities using sulfobutyl ether-beta-cyclodextrin (SBE-beta-CD) as a chiral selector. The use of 50 mM
## Abstract High resolution could be achieved for the enantiomers of acidic drugs, namely, sulindac, fenoprofen, ketoprofen, warfarin, and hexobarbital, in a buffer of pH 3 by the simultaneous addition of uncharged and charged β‐cyclodextrin derivatives. The interaction of the analytes with the ani