Enantioseparation of Flobufen with Cyclodextrins Studied by Capillary Electrophoresis and NMR
✍ Scribed by Alexandrine Lambert; Jean-Michel Ballon; Alain Nicolas
- Book ID
- 110297008
- Publisher
- Springer US
- Year
- 2001
- Tongue
- English
- Weight
- 212 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0724-8741
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## Abstract A sulfated β‐cyclodextrin (sulfated β‐CD)‐mediated capillary electrophoresis method is described for the enantioseparation of cetirizine using achiral cefazolin as an internal standard. The enantioseparation of the drug was performed in a borate buffer (5 mM, pH 8.7) with 1% sulfated β‐
Capillary electrophoresis (CE) allows the observation of the opposite affinities of the enantiomers of (±)-verapamil [2-isopropyl-2,8-bis(3,4-dimethoxyphenyl)-6-methyl-6-azaoctannitrile, VP] toward -cyclodextrin (-CD) and heptakis(2,3,6-tri-Omethyl)--CD (TM--CD). In addition, in the presence of