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Enantioselective total synthesis of (−)-preclavulone-A

✍ Scribed by E.J. Corey; Yi Bin Xiang


Book ID
103402327
Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
221 KB
Volume
29
Category
Article
ISSN
0040-4039

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A synthetic route to the preclavulone-A (3) analogs 11 and 14 via allene oxide and 2-oxidopentadienyl cation intermediates is described which is based on the proposed biosynthesis of 3. Clavuluriu viridis, a Pacific coral which produces the clavulone family of prostanoids (e.g. clavulone I (l)), co