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Asymmetric Synthesis of a Chiral Building Block for Cyclopentanoids: A Novel Enantioselective Synthesis of Preclavulone A
โ Scribed by Zanoni, Giuseppe; Porta, Alessio; Brunoldi, Enrico; Vidari, Giovanni
- Book ID
- 127271691
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 161 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0022-3263
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Both enantiomers of kainic acid have been synthesized from enantioenriched planar chiral cyclic amide 2a. The C3 and C4 stereocenters in the pyrrolidine ring were constructed by transannular Cope rearrangement of 2a, and the carboxyl group at the C2 position was introduced through lithiation followe