Enantioselective Total Synthesis of (−)-Lansai B and (+)-Nocardioazines A and B
✍ Scribed by Wang, Haoxuan; Reisman, Sarah E.
- Book ID
- 121747503
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 992 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0044-8249
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We have devised a total synthesis of (12R,13S,15R) salicylihalamides A and B, which allowed revision of the absolute stereochemistry of the natural compounds. The same strategy was then applied to the preparation of naturally occurring salicylihalamides.
We describe an expeditious enantioselective total synthesis of the acetylenic marine natural products (R)-strongylodiols A and B. Central to the strategy is the use of Zn(OTf) 2 , amine base, and N-methyl ephedrine to mediate the direct addition of a 1,3-diyne to two longchain aliphatic aldehydes in
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