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Enantioselective total synthesis of (R)-strongylodiols A and B

✍ Scribed by Stefan Reber; Thomas F Knöpfel; Erick M Carreira

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 145 KB
Volume: 59
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(03)00905-0

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✦ Synopsis

We describe an expeditious enantioselective total synthesis of the acetylenic marine natural products (R)-strongylodiols A and B. Central to the strategy is the use of Zn(OTf) 2 , amine base, and N-methyl ephedrine to mediate the direct addition of a 1,3-diyne to two longchain aliphatic aldehydes in useful selectivities and yields.

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