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Enantioselective total synthesis of (−)-epipodophyllotoxin and (−)-podophyllotoxin

✍ Scribed by R. Van Speybroeck; H. Guo; J. Van der Eycken; M. Vandewalle

Book ID: 104204011
Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 638 KB
Volume: 47
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)86473-5

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✦ Synopsis

An enantioselective total synthesis of (-)-epipodophyllotoxin (2) and hence of (-)-podophyllotoxin (I) is described, involving as key steps a conjugate addition on butenolide 13 as the chiral template, a stereoselective aldol condensation on lla and a stereoselective ring closure of 8.

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