✍ Scribed by Shreeshailkumar B Hadimani; Rajendra P Tanpure; Sujata V Bhat
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
A straightforward approach to podophyllotoxin was developed using silyl enol ether 5. Podophyllotoxin (1) is a lignan isolated from Podophyllum peltatum and p. ml. It is a potent inhibitor of microtubule assembly and a key intermediate of an antitumor agent, etoposide (2)'. Although there have bee
An enantioselective total synthesis of (-)-epipodophyllotoxin (2) and hence of (-)-podophyllotoxin (I) is described, involving as key steps a conjugate addition on butenolide 13 as the chiral template, a stereoselective aldol condensation on lla and a stereoselective ring closure of 8.