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Enantioselective total synthesis of anti HIV-1 active (+)-calanolide A through a quinine-catalyzed asymmetric intramolecular oxo-Michael addition
β Scribed by Tomohiro Tanaka; Takuya Kumamoto; Tsutomu Ishikawa
- Book ID
- 104211365
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 72 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Enantioselective total synthesis of anti HIV-1 active (+)-calanolide A was achieved by a quinine-catalyzed asymmetric intramolecular oxo-Michael addition as a key step.
π SIMILAR VOLUMES
2004 Other bioactive products ## Other bioactive products U 1300 Concise Synthesis of anti-HIV-1 Active (+)-Inophyllum B (Ib) and (+)-Calanolide A (Ia) by Application of (-)-Quinine-Catalyzed Intramolecular Oxo-Michael
Quinine effectively catalyzes an intramolecular Michael-type addition of 7-hy&oxy-8tigloylcoumarin to give a diastereoisomeric mixture of the corresponding cyclized coumarin with a 2,3dimethyl-4-chromanone skeleton. Satisfactory enantioseleetivity was observed in a cis-chromanone construction, but n