2004 Other bioactive products ## Other bioactive products U 1300 Concise Synthesis of anti-HIV-1 Active (+)-Inophyllum B (Ib) and (+)-Calanolide A (Ia) by Application of (-)-Quinine-Catalyzed Intramolecular Oxo-Michael
Concise Synthesis of Anti-HIV-1 Active (+)-Inophyllum B and (+)-Calanolide A by Application of (−)-Quinine-Catalyzed Intramolecular Oxo-Michael Addition
✍ Scribed by Sekino, Etsuko; Kumamoto, Takuya; Tanaka, Tomohiro; Ikeda, Tomoko; Ishikawa, Tsutomu
- Book ID
- 121469794
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 175 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
Enantioselective total synthesis of anti HIV-1 active (+)-calanolide A was achieved by a quinine-catalyzed asymmetric intramolecular oxo-Michael addition as a key step.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Quinine effectively catalyzes an intramolecular Michael-type addition of 7-hy&oxy-8tigloylcoumarin to give a diastereoisomeric mixture of the corresponding cyclized coumarin with a 2,3dimethyl-4-chromanone skeleton. Satisfactory enantioseleetivity was observed in a cis-chromanone construction, but n