✦ LIBER ✦
An approach to anti-HIV-1 active Calophyllum coumarin synthesis: An enantioselective construction of 2,3-dimethyl-4-chromanone ring by quinine-assisted intramolecular Michael-type addition
✍ Scribed by Tsutomu Ishikawa; Yumie Oku; Tomohiro Tanaka; Takuya Kumamoto
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 211 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Quinine effectively catalyzes an intramolecular Michael-type addition of 7-hy&oxy-8tigloylcoumarin to give a diastereoisomeric mixture of the corresponding cyclized coumarin with a 2,3dimethyl-4-chromanone skeleton. Satisfactory enantioseleetivity was observed in a cis-chromanone construction, but not in a trans-one.