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Enantioselective Synthesis of ε-Lactones by Lipase-Catalyzed Resolution

✍ Scribed by Shimotori, Yasutaka; Aoyama, Masakazu; Tsukasa, Hidetaka; Miyakoshi, Tetsuo

Book ID
118247495
Publisher
Japan Institute of Heterocyclic Chemistry
Year
2012
Tongue
English
Weight
783 KB
Volume
85
Category
Article
ISSN
0385-5414

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Synthesis of optically active γ-lactones
Synthesis of optically active γ-lactones via lipase-catalyzed resolution
✍ Yasutaka Shimotori; Yukihiko Nakahachi; Keita Inoue; Tetsuo Miyakoshi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 326 KB

## Abstract Both enantiomers of the six major kinds of __γ__‐lactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various __rac__‐__N__‐methyl‐4‐hydroxyalkanamides via Grignard reaction and the enantioselective acetylatio