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Enantioselective synthesis of α-amino acids from nitroalkenes

✍ Scribed by Stéphane Sabelle; Denis Lucet; Thierry Le Gall; Charles Mioskowski


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
192 KB
Volume
39
Category
Article
ISSN
0040-4039

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📜 SIMILAR VOLUMES


ChemInform Abstract: Enantioselective Sy
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Enantioselective Synthesis of α-Amino Acids from Nitroalkenes. -Careful oxidation of the addition products (I) of (R)-4-phenyl-2-oxazolidine and nitroalkenes yields the acids (II) which can be easily cleaved to D-α-amino acids of high optical purity.

ChemInform Abstract: Enantioselective Sy
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Enantioselective synthesis of α-amino ac
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Enantioselective syntheses of optically active or-amino acids from glycine t-butyl ester through Schiff base employing (+)-N-alkyl-10-camphorsulfonamides as chiral auxiliaries were described. Methylation of Schiff base 5 gave high asymmetric inductions, whereas ethylation, allylation and benzylation

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We present two complementary methods for the stereoselective synthesis of non-natural alpha-amino acids with aromatic or heteroaromatic side chains. One approach is based on the chemical transformation of methionine, whereas the other applies the stereoselective Myers alkylation of glycine. The resu