## Abstract The polycyclic aromatic hydrocarbons (PAHs) dibenzo[__a,l__]pyrene (DBP) and benzo[__a__]pyrene (BP) are environmental contaminants and potent carcinogens. DBP is several orders of magnitude more mutagenic/carcinogenic than BP. This can be ascribed to differences in DNA binding efficien
Enantioselective synthesis of the tumorigenic anti-diol epoxide metabolites of benzo[a]pyrene
β Scribed by Ronald G. Harvey; Xiao-Qing Tang
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 241 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The frequency of cell transformation was determined after treatment of normal hamster embryo cells with benzo(a)pyrene (BP) and six of its metabolites. These metabolites included the __trans__ 4,5β, 7,8β and 9,10βdihydrodiols; the 4,5βepoxide; and two stereoisomers of the nonβKβregion d
The objective of this study was to investigate whether polycyclic aromatic hydrocarbons (PAHs) contribute to the etiology of sporadic breast cancer by altering the expression of BRCA-1. Acute exposure to the PAH benzo[a]pyrene (B[a]P) inhibited in a time-and dose-dependent fashion cell proliferation