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Enantioselective Synthesis of Spirooxindole α- exo -Methylene-γ-butyrolactones from 3-OBoc-Oxindoles

✍ Scribed by Jayakumar, Samydurai; Muthusamy, Subramaniam; Prakash, Muthuraj; Kesavan, Venkitasamy


Book ID
121786524
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
563 KB
Volume
2014
Category
Article
ISSN
1434-193X

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Enantioselective synthesis of α-methylen
✍ Chinnasamy Muthiah; Midori A. Arai; Toshio Shinohara; Takayoshi Arai; Shinobu Ta 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 186 KB

Combination of Pd(OCOCF 3 ) 2 and (M,S,S)-iPr-SPRIX ligand promoted the intramolecular cyclization of 2-alkynoates very effectively to form a-methylene-g-butyrolactones in good yields with up to 92% ee.