A Practical Synthesis of (R)-(-)-Phenylephrine Hydrochloride. -An asymmetric synthesis of title compound (IV) is developed based on hydrolytic kinetic resolution of the styrene oxide (I) using a (R,R)-Salen-Co-OAc complex. -(GURJAR, MUKUND K.;
Enantioselective synthesis of (R)-phenylephrine hydrochloride
โ Scribed by Rajesh Kumar Pandey; Puspesh Kumar Upadhyay; Pradeep Kumar
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 84 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
An efficient method for the synthesis of enantiomerically pure (R)-phenylephrine hydrochloride 1 is described using a Sharpless asymmetric dihydroxylation as the key step.
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