Enantioselective synthesis of R-(+)-?-lipoic acid
โ Scribed by Page, Philip C. Bulman; Rayner, Christopher M.; Sutherland, Ian O.
- Book ID
- 121195619
- Publisher
- The Royal Society of Chemistry
- Year
- 1986
- Tongue
- English
- Weight
- 157 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-4936
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The asymmetric synthesis of methyl (S)-6,8-dihydroxyoctanoate ( ) and (S)-6,8-dimethylsulfonyloxyoctane-1-carboxylic acid (13), key precursors to R-(+)-a-lipoic acid (6) is described using OsO 4 -catalyzed asymmetric dihydroxylation and Ru-catalyzed asymmetric hydrogenation, respectively, as the key
An efficient enantioselective synthesis of (R)-(+)-a-lipoic acid is described, in high optical purity (>97% ee), using L-proline-catalyzed sequential a-aminoxylation and Horner-Wadsworth-Emmons olefination of aldehyde as the key step.
1997 hydroxycarboxylic acids hydroxycarboxylic acids (ether carboxylic acids) (acyclic compounds) and esters P 0280 15 -077 A Short Enantioselective Formal Synthesis of Methyl (S)-(-)-6,8-Dihydroxyoctanoate: A Key Intermediate for the Synthesis of (R)-(+)-. alpha.-Lipoic Acid. -The enantioselective