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Enantioselective synthesis of (R)-(+)-α-lipoic acid via proline-catalyzed sequential α-aminoxylation and HWE olefination of aldehyde

✍ Scribed by Sharad P. Panchgalle; Ganesh F. Jogdand; Subhash P. Chavan; Uttam R. Kalkote

Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 291 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.05.007

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✦ Synopsis

An efficient enantioselective synthesis of (R)-(+)-a-lipoic acid is described, in high optical purity (>97% ee), using L-proline-catalyzed sequential a-aminoxylation and Horner-Wadsworth-Emmons olefination of aldehyde as the key step.

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