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Enantioselective Synthesis of ( R )- and ( S )-4-Benzyloxy-2-cyclohexen-1-one

✍ Scribed by Suzuki, Hidetaka; Yamazaki, Naoki; Kibayashi, Chihiro


Book ID
127344776
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
43 KB
Volume
66
Category
Article
ISSN
0022-3263

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A Practical Synthesis of Enantiopure (R)
✍ Gebauer, Olaf ;BrΓΌckner, Reinhard πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 590 KB

## Abstract The title compound __R__‐4a was prepared from (–)‐quinic acid (1) in 6 steps in 18% overall yield (Scheme 3) and with 100% enantiomeric purity (Figure 1). The initiating step is the regio‐ and stereoselective acetalization of the __trans__‐oriented vicinal OH groups of 1 (+ 5 β†’ 8). Alco