An Improved Synthesis of 4-Methylene-2-cyclohexen-1-one
β Scribed by Jung, Michael E.; Rayle, Heather L.
- Book ID
- 120370665
- Publisher
- Taylor and Francis Group
- Year
- 1994
- Tongue
- English
- Weight
- 260 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0039-7911
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A one pot synthesis of (E)-4-alkylidene-2-cyclohexen-l-ones 2 via a cross coupling of 2-( l-acetoxy alkyl) enones 1 and aliphatic 1,3-diketones in the presence of anhydrous potassium carbonate in absolute ethanol at reflux, is reported.
## Abstract The title compound __R__β4a was prepared from (β)βquinic acid (1) in 6 steps in 18% overall yield (Scheme 3) and with 100% enantiomeric purity (Figure 1). The initiating step is the regioβ and stereoselective acetalization of the __trans__βoriented vicinal OH groups of 1 (+ 5 β 8). Alco