A convenient synthesis of 2S, 3S-[3-2H]-
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Lawrence Slieker; Stephen J. Benkovic
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Article
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1982
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John Wiley and Sons
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French
β 380 KB
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Both 2S,3R-[2,3-2H2]-serine 5 and 2S,3S-[3-2H]-serine 6 have been pre ared from (E)-methyl-[2,3-2H2]-acrylate and (Z)-ethyl-[3-qH]-acrylate, respectively. The acrylate esters were converted to a mixture of isomeric bromohydrins by treatment with N-bromoacetamide. The ratio of 2-bromo-3-hydroxy speci