Enantioselective synthesis of (R)- and (S)-2-alkyl-1,4-butanediolsvia enantiomerically pure 3-alkyl-5-(menthyloxy)butyrolactones
β Scribed by Namkyu Lee; Young-Woo Kim; Kieyoung Chang; Key H. Kim; Sang-Sup Jew; Dae-Kee Kim
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 281 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The alkylation of the dianion of the title compound (2), readily prepared from (S)malic acid, with w-iodo-l-trimethylsilyl-2-alkynes (8a-c) occurs with high trans-selectivity with respect to the hydroxyl function. The productsTITa-c) cyclize in formic acid to enantiomerically pure azabicyclic allene
## Abstract For Abstract see ChemInform Abstract in Full Text.
A synthesis of cage-shaped compounds-(IS,4S,5R)-4-hydroxy-2,6diazabicyclo[3.3.0]octane and (1S,4R,5R)-4-hydroxy-2-oxa-6-azabicyclo[3.3.0]octane described. The test for enantioselective catalysis also reported.