✦ LIBER ✦

Diastereoselective alkylation of the dianion of 5-ethoxy-4(S)-hydroxy-1-isopropyl-2-pyrrolidinone; Synthesis of enantiomerically pure azabicycles

✍ Scribed by Wim J. Klaver; Henk Hiemstra; W.Nico Speckamp

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 281 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)81047-9

No coin nor oath required. For personal study only.

✦ Synopsis

The alkylation of the dianion of the title compound (2), readily prepared from (S)malic acid, with w-iodo-l-trimethylsilyl-2-alkynes (8a-c) occurs with high trans-selectivity with respect to the hydroxyl function. The productsTITa-c) cyclize in formic acid to enantiomerically pure azabicyclic allenes (12a-c), one of wah-(12b) might be a suitable precursor to peduncularine (15).

📜 SIMILAR VOLUMES

Enantioselective synthesis of (R)- and (

Enantioselective synthesis of (R)- and (S)-2-alkyl-1,4-butanediolsvia enantiomerically pure 3-alkyl-5-(menthyloxy)butyrolactones

✍ Namkyu Lee; Young-Woo Kim; Kieyoung Chang; Key H. Kim; Sang-Sup Jew; Dae-Kee Kim 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 281 KB

ChemInform Abstract: Synthesis of Enanti

ChemInform Abstract: Synthesis of Enantiomerically Pure α-Amino Acids via Chemo- and Diastereoselective Alkylation of (5S)-5-Phenyl-5,6-dihydro-2H-1,4-oxazin-2-one.

✍ L. M. HARWOOD; S. N. G. TYLER; A. S. ANSLOW; I. D. MACGILP; M. G. B. DREW 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

ChemInform Abstract: (4R,5S)-1,5-Dimethy

ChemInform Abstract: (4R,5S)-1,5-Dimethyl-4-phenylimidazolidin-2-one as a Chiral Auxiliary for the Diastereoselective Alkylation of a New Iminic Glycine Derivative: Practical Asymmetric Synthesis of α-Amino Acids.

✍ G. GUILLENA; C. NAJERA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views