Enantiomerically pure cage-shaped (1S,4S,5R)-4-hydroxy-2,6-diazabicyclo[3.3.0]octane and (1S,4R,5R)-4-hydroxy-2-oxa-6-azabicyclo[3.3.0]octane: Synthesis and test for enantioselective catalysis
β Scribed by Guo-qiang Lin; Zhi-cai Shi
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 695 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4020
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β¦ Synopsis
A synthesis of cage-shaped compounds-(IS,4S,5R)-4-hydroxy-2,6diazabicyclo[3.3.0]octane and (1S,4R,5R)-4-hydroxy-2-oxa-6-azabicyclo[3.3.0]octane described. The test for enantioselective catalysis also reported.
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## Abstract Lipase Amano PS is a suitable biocatalyst for the highly regioβ and enantioselective transesterification of the racemic prostaglandin building block (1__S__~\*~,5__R__\*,6__R__\*,7__R__\*)β(Β±)β7βhydroxyβ6βhydroxymethylβ2βoxabicyclo[3.3.0]octanβ3βone (__rac__β1) yielding (1__S__,5__R__,6