Enantioselective synthesis of enantiomeric 1,3-dideuteroallenes

✍ Scribed by Gy.M. Keserü; M. Nógrádi; J. Rétey; J. Robinson

• Book ID: 104207494
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 335 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(96)01139-8

✦ Synopsis

Ab~ract: (R)-l,3-2H2-Prop-2-yn-l-ot [(R)-21 was obtained by enzymatic deuteration of prop-2-yn-l-ol.

Methoxymethylation and thermal rearrangement of (R)-2 gave (33-(1,3-2H2)allene (33-1, while reaction of (R)-l-2H2-prop-2-yn-l-ol [(R)-2a] with MeOC2H2CI followed by thermolysis afforded (R)-(l,3-2H2)allene (R)-I, the lightest chiral molecules composed