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Enantioselective Synthesis of a GPR40 Agonist AMG 837 via Catalytic Asymmetric Conjugate Addition of Terminal Alkyne to α,β-Unsaturated Thioamide

✍ Scribed by Yazaki, Ryo; Kumagai, Naoya; Shibasaki, Masakatsu


Book ID
111880314
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
942 KB
Volume
13
Category
Article
ISSN
1523-7060

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## Abstract Key feature of the title conjugate addition reaction is the cooperative activation of both the alkyne and the thioamide by a combined soft Lewis acid—hard Broensted base catalyst system.

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