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Cooperative Activation of Alkyne and Thioamide Functionalities; Direct Catalytic Asymmetric Conjugate Addition of Terminal Alkynes to α,β-Unsaturated Thioamides

✍ Scribed by Ryo Yazaki; Dr. Naoya Kumagai; Prof. Dr. Masakatsu Shibasaki


Book ID
112006311
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
571 KB
Volume
6
Category
Article
ISSN
1861-4728

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ChemInform Abstract: Cooperative Activat
✍ Ryo Yazaki; Naoya Kumagai; Masakatsu Shibasaki 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 80 KB 👁 2 views

## Abstract Key feature of the title conjugate addition reaction is the cooperative activation of both the alkyne and the thioamide by a combined soft Lewis acid—hard Broensted base catalyst system.